Trolamine salicylate (TS) is a topical anti-inflammatory analgesic used to treat small joint\npain. The topical route is preferred over the oral one owing to gastrointestinal side effects. In this study,\na poly(lactide-co-glycolide) (PLGA)-based in situ bio-adhesive film-forming system for the transdermal\ndelivery of TS was designed and evaluated. Therefore, varying amounts (0%, 5%, 10%, 20%, and\n25% (w/w)) of PLGA (EXPANSORB® DLG 50-2A, 50-5A, 50-8A, and 75-5A), ethyl 2-cyanoacrylate,\npoly (ethylene glycol) 400, and 1% of TS were dissolved together in acetone to form the bio-adhesive\npolymeric solution. In vitro drug permeation studies were performed on a vertical Franz diffusion cell\nand dermatomed porcine ear skin to evaluate the distinct formulations. The bio-adhesive polymeric\nsolutions were prepared successfully and formed a thin film upon application in situ. A significantly\nhigher amount of TS was delivered from a formulation containing 20% PLGA����..
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